Integrated graph measures reveal survival likelihood for buildings in wildfre events

Wildfre events have resulted in unprecedented social and economic losses worldwide in the last few years. Most studies on reducing wildfre risk to communities focused on modeling wildfre behavior in the wildland to aid in developing fuel reduction and fre suppression strategies. However, minimizing losses in communities and managing risk requires a holistic approach to understanding wildfre behavior that fully integrates the wildland’s characteristics and the built environment’s features. This complete integration is particularly critical for intermixed communities where the wildland and the built environment coalesce. Community-level wildfre behavior that captures the interaction between the wildland and the built environment, which is necessary for predicting structural damage, has not received sufcient attention. Predicting damage to the built environment is essential in understanding and developing fre mitigation strategies to make communities more resilient to wildfre events. In this study, we use integrated concepts from graph theory to establish a relative vulnerability metric capable of quantifying the survival likelihood of individual buildings within a wildfre-afected region. We test the framework by emulating the damage observed in the historic 2018 Camp Fire and the 2020 Glass Fire. We propose two formulations based on graph centralities to evaluate the vulnerability of buildings relative to each other. We then utilize the relative vulnerability values to determine the damage state of individual buildings. Based on a one-to-one comparison of the calculated and observed damages, the maximum predicted building survival accuracy for the two formulations ranged from 58 − 64% for the historical wildfres tested. From the results, we observe that the modifed random walk formulation can better identify nodes that lie at the extremes on the vulnerability scale. In contrast, the modifed degree formulation provides better predictions for nodes with mid-range vulnerability values

Characterizing the rate of spread of large wildfires in emerging fire environments of northwestern Europe using visible infrared imaging radiometer suite active fire data

In recent years fires of greater magnitude have been documented throughout northwest Europe. With several climate projections indicating future increases in fire activity in this temperate area, it is imperative to identify the status of fire in this region. This study unravels unknowns about the state of the fire regime in northwest Europe by characterizing one of the key aspects of fire behavior, the rate of spread (ROS). Using an innovative approach to cluster Visible Infrared Imaging Radiometer Suite (VIIRS) hotspots into fire perimeter isochrones to derive ROS, we identify the effects of land cover and season on the rate of spread of 102 landscape fires that occurred between 2012 and 2022. Results reveal significant differences between land cover types, and there is a clear peak of ROS and burned area in the months of March and April. Median ROS within these peak months is approximately 0.09 km h−1 during a 12 h overpass, and 66 % of the burned area occurs in this spring period. Heightened ROS and burned area values persist in the bordering months of February and May, suggesting that these months may present the extent of the main fire season in northwest Europe. Accurate data on ROS among the represented land cover types, as well as periods of peak activity, are essential for determining periods of elevated fire risk, the effectiveness of available suppression techniques, and appropriate mitigation strategies (land and fuel management).This project has received funding from the European Union's Horizon 2020 research and innovation program under the Marie Skłodowska-Curie grant agreement no. 860787 (PyroLife Innovative Training Network; https://pyrolife.lessonsonfire.eu/, last access: January 2023), a project in which a new generation of experts is trained in integrated fire manageme

Slower growth during lactation rescues early cardiovascular and adipose tissue hypertrophy induced by fetal undernutrition in rats

Low birth weight (LBW) and accelerated growth during lactation are associated with cardiometabolic disease development. LBW offspring from rats exposed to undernutrition during gestation (MUN) develops hypertension. In this rat model, we tested if slower postnatal growth improves early cardiometabolic alterations. MUN dams were fed ad libitum during gestation days 1–10, with 50% of the daily intake during days 11–21 and ad libitum during lactation. Control dams were always fed ad libitum. Pups were maintained with their own mother or cross-fostered. Body weight and length were recorded weekly, and breastmilk was obtained. At weaning, the heart was evaluated by echocardiography, and aorta structure and adipocytes in white perivascular fat were studied by confocal microscopy (size, % beige-adipocytes by Mitotracker staining). Breastmilk protein and fat content were not significantly different between groups. Compared to controls, MUN males significantly accelerated body weight gain during the exclusive lactation period (days 1–14) while females accelerated during the last week; length growth was slower in MUN rats from both sexes. By weaning, MUN males, but not females, showed reduced diastolic function and hypertrophy in the heart, aorta, and adipocytes; the percentage of beige-type adipocytes was smaller in MUN males and females. Fostering MUN offspring on control dams significantly reduced weight gain rate, cardiovascular, and fat hypertrophy, increasing beige-adipocyte proportion. Control offspring nursed by MUN mothers reduced body growth gain, without cardiovascular modifications. In conclusion, slower growth during lactation can rescue early cardiovascular alterations induced by fetal undernutrition. Exclusive lactation was a key period, despite no modifications in breastmilk macronutrients, suggesting the role of bioactive components. Our data support that lactation is a key period to counteract cardiometabolic disease programming in LBW and a potential intervention window for the mothe

A Bespoke Workflow Management System for Data-Driven Urgent HPC

In this paper we present a workflow management system which permits the kinds of data-driven workflows required by urgent computing, namely where new data is integrated into the workflow as a disaster progresses in order refine the predictions as time goes on. This allows the workflow toadapt to new data at runtime, a capability that most workflow management systems do not possess. The workflow management system was developed for the EU-funded VESTEC project, which aims to fuse HPC with real-time data for supporting urgent decision making. We first describe an example workflow from the VESTEC project, and show why existing workflow technologies do not meet the needs of the project. We then go on to present the design of our Workflow Management System, describe how it is implemented into the VESTEC system, and provide an example of the workflow system in use for a test case

Precisiones sobre el significado general de la palabra dibujo con vistas a una especificación de algunos de sus significados particulares

Junta de Andalucía-Consejería de Política TerritorialEscuela Técnica Superior de Arquitectura de la Universidad de SevillaExcmo. Ayuntamiento de SevillaColegio Oficial de Arquitectos de Andalucía Occidenta

Fire behavior modeling for operational decision-making

Simulation frameworks are necessary to facilitate decision-making to many fire agencies. An accurate estimation of fire behavior is required to analyze potential impact and risk. Applied research and technology together have improved the implementation of fire modeling, and decision-making in operational environments.Dr Cardil acknowledges the support of Technosylva USA and Wageningen University in his research stays in the USA and the Netherlands to develop this work. The authors of this paper acknowledges the support of the EUfunded PYROLIFE project (Reference: 860787; https://pyrolife.lessonsonfire.eu/), a project in which a new generation of experts will be trained in integrated wildfire management

Slower growth during lactation rescues early cardiovascular and adipose tissue hypertrophy induced by fetal undernutrition in rats

Low birth weight (LBW) and accelerated growth during lactation are associated with cardiometabolic disease development. LBW offspring from rats exposed to undernutrition during gestation (MUN) develops hypertension. In this rat model, we tested if slower postnatal growth improves early cardiometabolic alterations. MUN dams were fed ad libitum during gestation days 1–10, with 50% of the daily intake during days 11–21 and ad libitum during lactation. Control dams were always fed ad libitum. Pups were maintained with their own mother or cross-fostered. Body weight and length were recorded weekly, and breastmilk was obtained. At weaning, the heart was evaluated by echocardiography, and aorta structure and adipocytes in white perivascular fat were studied by confocal microscopy (size, % beige-adipocytes by Mitotracker staining). Breastmilk protein and fat content were not significantly different between groups. Compared to controls, MUN males significantly accelerated body weight gain during the exclusive lactation period (days 1–14) while females accelerated during the last week; length growth was slower in MUN rats from both sexes. By weaning, MUN males, but not females, showed reduced diastolic function and hypertrophy in the heart, aorta, and adipocytes; the percentage of beige-type adipocytes was smaller in MUN males and females. Fostering MUN offspring on control dams significantly reduced weight gain rate, cardiovascular, and fat hypertrophy, increasing beige-adipocyte proportion. Control offspring nursed by MUN mothers reduced body growth gain, without cardiovascular modifications. In conclusion, slower growth during lactation can rescue early cardiovascular alterations induced by fetal undernutrition. Exclusive lactation was a key period, despite no modifications in breastmilk macronutrients, suggesting the role of bioactive components. Our data support that lactation is a key period to counteract cardiometabolic disease programming in LBW and a potential intervention window for the mothe

The global, regional, and national burden of adult lip, oral, and pharyngeal cancer in 204 countries and territories:A systematic analysis for the Global Burden of Disease Study 2019

Importance Lip, oral, and pharyngeal cancers are important contributors to cancer burden worldwide, and a comprehensive evaluation of their burden globally, regionally, and nationally is crucial for effective policy planning.Objective To analyze the total and risk-attributable burden of lip and oral cavity cancer (LOC) and other pharyngeal cancer (OPC) for 204 countries and territories and by Socio-demographic Index (SDI) using 2019 Global Burden of Diseases, Injuries, and Risk Factors (GBD) Study estimates.Evidence Review The incidence, mortality, and disability-adjusted life years (DALYs) due to LOC and OPC from 1990 to 2019 were estimated using GBD 2019 methods. The GBD 2019 comparative risk assessment framework was used to estimate the proportion of deaths and DALYs for LOC and OPC attributable to smoking, tobacco, and alcohol consumption in 2019.Findings In 2019, 370 000 (95% uncertainty interval [UI], 338 000-401 000) cases and 199 000 (95% UI, 181 000-217 000) deaths for LOC and 167 000 (95% UI, 153 000-180 000) cases and 114 000 (95% UI, 103 000-126 000) deaths for OPC were estimated to occur globally, contributing 5.5 million (95% UI, 5.0-6.0 million) and 3.2 million (95% UI, 2.9-3.6 million) DALYs, respectively. From 1990 to 2019, low-middle and low SDI regions consistently showed the highest age-standardized mortality rates due to LOC and OPC, while the high SDI strata exhibited age-standardized incidence rates decreasing for LOC and increasing for OPC. Globally in 2019, smoking had the greatest contribution to risk-attributable OPC deaths for both sexes (55.8% [95% UI, 49.2%-62.0%] of all OPC deaths in male individuals and 17.4% [95% UI, 13.8%-21.2%] of all OPC deaths in female individuals). Smoking and alcohol both contributed to substantial LOC deaths globally among male individuals (42.3% [95% UI, 35.2%-48.6%] and 40.2% [95% UI, 33.3%-46.8%] of all risk-attributable cancer deaths, respectively), while chewing tobacco contributed to the greatest attributable LOC deaths among female individuals (27.6% [95% UI, 21.5%-33.8%]), driven by high risk-attributable burden in South and Southeast Asia.Conclusions and Relevance In this systematic analysis, disparities in LOC and OPC burden existed across the SDI spectrum, and a considerable percentage of burden was attributable to tobacco and alcohol use. These estimates can contribute to an understanding of the distribution and disparities in LOC and OPC burden globally and support cancer control planning efforts

Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study

Funder: European Society of Intensive Care Medicine; doi: http://dx.doi.org/10.13039/501100013347Funder: Flemish Society for Critical Care NursesAbstract: Purpose: Intensive care unit (ICU) patients are particularly susceptible to developing pressure injuries. Epidemiologic data is however unavailable. We aimed to provide an international picture of the extent of pressure injuries and factors associated with ICU-acquired pressure injuries in adult ICU patients. Methods: International 1-day point-prevalence study; follow-up for outcome assessment until hospital discharge (maximum 12 weeks). Factors associated with ICU-acquired pressure injury and hospital mortality were assessed by generalised linear mixed-effects regression analysis. Results: Data from 13,254 patients in 1117 ICUs (90 countries) revealed 6747 pressure injuries; 3997 (59.2%) were ICU-acquired. Overall prevalence was 26.6% (95% confidence interval [CI] 25.9–27.3). ICU-acquired prevalence was 16.2% (95% CI 15.6–16.8). Sacrum (37%) and heels (19.5%) were most affected. Factors independently associated with ICU-acquired pressure injuries were older age, male sex, being underweight, emergency surgery, higher Simplified Acute Physiology Score II, Braden score 3 days, comorbidities (chronic obstructive pulmonary disease, immunodeficiency), organ support (renal replacement, mechanical ventilation on ICU admission), and being in a low or lower-middle income-economy. Gradually increasing associations with mortality were identified for increasing severity of pressure injury: stage I (odds ratio [OR] 1.5; 95% CI 1.2–1.8), stage II (OR 1.6; 95% CI 1.4–1.9), and stage III or worse (OR 2.8; 95% CI 2.3–3.3). Conclusion: Pressure injuries are common in adult ICU patients. ICU-acquired pressure injuries are associated with mainly intrinsic factors and mortality. Optimal care standards, increased awareness, appropriate resource allocation, and further research into optimal prevention are pivotal to tackle this important patient safety threat